Roles of Aromatic Residues in High Interfacial Activity of Naja naja atra Phospholipase A2
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چکیده
منابع مشابه
Roles of aromatic residues in high interfacial activity of naja naja atra phospholipase A(2)
Acidic phospholipase A2 (PLA2) from the venom of Chinese cobra (Naja naja atra) has high activity on zwitterionic membranes and contains six aromatic residues, including Tyr-3, Trp-18, Trp-19, Trp-61, Phe-64, and Tyr-110, on its putative interfacial binding surface. To assess the roles of these aromatic residues in the interfacial catalysis of N. n. atra PLA2, we mutated them to Ala and measure...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2000
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi005105t